Method of inhibiting leukotriene biosynthesis by oral administra

Details Method of inhibiting leukotriene biosynthesis by oral administra Method of inhibiting leukotriene biosynthesis by oral administra

1988-02-19

1990-03-20

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514312, 514534, 514546, 514654, 514655, 514657, 514826, 514863, A61K 3124, A61K 3147

Patent

active

049102087

ABSTRACT:
A method is provided for inhibiting leukotriene biosynthesis and thus treating asthma, psoriasis or inflammation by oral administration of p-aminophenols having the structure ##STR1## wherein m is 0 to 5; X is CH or N; R.sup.1 and R.sup.2 may be the same or different and are H, lower alkyl, aryl, hydroxy, hydroxyalkyleneoxy, alkylthio, alkoxy, alkanoyloxy, aryloxy, halo, carboxy, alkoxycarbonyl or amido; R.sup.3 is H, lower alkyl, alkanoyl or aroyl; and R.sup.4 is H, lower alkyl, benzoyl or alkanoyl, and including acid-addition salts thereof, with the proviso that when R.sup.4 is benzoyl, R.sup.2 is other than H.

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