Size limited double stranded poly I poly(cytidylate/4-thiouridyl

Details Size limited double stranded poly I poly(cytidylate/4-thiouridyl Size limited double stranded poly I poly(cytidylate/4-thiouridyl

1989-04-06

1994-03-29

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 251, 536 2853, C07H 2102

Patent

active

052986144

ABSTRACT:
Nucleic acid derivatives and pharmaceutical compositions containing such derivatives are produced containing one 4-thiouridylic acid for every 6 to 39 cytidylic acids present, which has a length of from 50 to 10,000 base pairs. Methods of treatment using these nucleic acid derivatives to treat viral infections is also described.

REFERENCES:
patent: 4315919 (1982-02-01), Shanbrom
Kochetkov et al., Organic Chemistry of Nucleic Acids, Part A, Plenum Press, New York, N.Y., 1971, see pp. 20 and 238.
Lehninger, Biochemistry, 2nd Ed., Worth Publishers, New York, N.Y., 1975, see pp. 159-160 and 966-972.
Thompson et al., Methods in Enzymology, vol. 100, 369-399 (1983).
Wells et al., Methods in Enzymology, vol. 65, 327-347 (1980).
Kanter et al., Anal. Biochem. 97, 77-84 (1979).
Ho et al., "Enzymatic Synthesis of Polyuridylic Acid Containing Modified Bases," Nucleic Acids Res., 8(14), 3175-3191 (1980).
Favre et al., "Intramolecular Cross-linking of Single-Stranded Copolymers of 4-Thiouridine and Cytidine," Biochem, Biophys. Res. Comm., 58(2), 507-515 (1974).
Iris L. Doerr, I. Wempen, Donald A. Clarke and Jack J. Fox, Journal of Organic Chemistry, vol. 26, pp. 3401-3409 (1961).

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