Inhibition of the advanced glycosylation of proteins using subst

Details Inhibition of the advanced glycosylation of proteins using subst Inhibition of the advanced glycosylation of proteins using subst

1992-12-08

1994-06-07

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

424 49, A61K 3141, A61K 716

Patent

active

053189825

ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises substituted 1,2,4-triazoles capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

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Brownlee et al., Science, 232:1629-1632 (1986).
Brownlee et al., Diabetes, 35 Suppl. 1, p. 42A (1986).
Nordbo, J. Dent. Res. 58:1429 (1979).

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