Platelet aggregation inhibitors

Details Platelet aggregation inhibitors Platelet aggregation inhibitors

1990-02-20

1994-06-07

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 235, 4353201, 4352523, 4351721, 514 2, C12P 2106

Patent

active

053188993

ABSTRACT:
An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K.sup.* -(G/Sar)-D wherein K.sup.* is a modified lysyl residue of the formula

REFERENCES:
patent: 4652639 (1987-03-01), Stabinsky
Knudsen et al., Exp. Cell Res (1988) pp. 42-49 1988.
Huang et al. Toxicon 22(2) 243-252 1984.
Huang et al. BBACA 925(3) 248-257 1987.
Kosogi et al. Snake 17(2) pp 117-123 1985.
Ouyang et al. Toxicon 21(6) 797-804 1983.

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