Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-09-10
1994-03-29
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546337, A61K 3144, C07D21172
Patent
active
052985148
ABSTRACT:
The present invention relates to phenolic thioetheramides of the formula ##STR1## wherein R.sup.1 and R.sup.2 are tert-alkyl or phenyl, Alk.sup.1 and Alk.sup.2 are alkylene; X is sulfur or oxygen, m is 0, 1, or 2; and R is ##STR2## wherein R.sup.3 and R.sup.4 are hydrogen or alkyl and Alk.sup.3 is alkylene.
REFERENCES:
patent: 4029812 (1977-06-01), Wagner et al.
patent: 4076841 (1978-02-01), Wagner et al.
patent: 4078084 (1978-03-01), Wagner et al.
patent: 4153803 (1979-05-01), Thiele et al.
patent: 4621098 (1986-11-01), Umminger et al.
patent: 4663333 (1987-05-01), Mueller et al.
patent: 4711903 (1987-12-01), Mueller et al.
patent: 4755524 (1988-07-01), Mueller et al.
patent: 4857558 (1989-08-01), Mueller
Goodman and Gilman's, The Pharmacological Basis of Therapeutics (7th Edition, 1985), pp. 660-673.
Badwey, J. A., et al., "cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils," J. Biol. Chem., 256:12640-12643, (1981).
Carroll E. Cross, et al. "Oxygen Radicals and Human Disease," Annals of Internal Medicine, vol. 107, No. 4, Oct., 1987, pp. 526-545, U.S.A.
Peter A. Ward, et al. "Oxygen Radicals, Inflammation, and Tissue Injury," Free Radical Biology and Medicine, vol. 5, 1988, pp. 403-408, U.S.A.
Virginia L. Shepherd "The Role of the Respiratory Burst of Phagocytes in Host Defense," Seminars in Respiratory Infections, vol. 1, No. 2, Jun., 1986, pp. 99-106, U.S.A.
Rakesh C. Kukreja, et al. "PGH Synthase and Lipoxygenase Generate Superoxide in the Presence of NADH or NADPH," Circulation Research, vol. 59, No. 6, Dec., 1986, pp. 612-619, U.S.A.
K. Katayana, et al. "In vitro effect of N-methoxy-3-(3,5-diert-butyl-4-hydroxy-benzylidene)-2-pyrrolidone (E-5110), a novel nonsteroidal anti-inflammatory agent, on generation of some inflammatory mediators," Agents and Actions, vol. 21, 3/4, 1987, pp. 269-271, Switzerland.
P. Biemond, et al. "Diminished Superoxide Production of Synovial Fluid Neutrophils in Patients with Rheumatoid Arthritis Following Piroxicam Treatment," Scand J. Rheumatology, 19, 1990, pp. 151-156, Netherlands.
W. Kreutner, et al. "Antiallergy Activity of Sch 37224, a New Inhibitor of Leukotriene Formation," The Journal of Pharmacology and Experimental Therapeutics, vol. 247, No. 3, 1988, pp. 997-1003, U.S.A.
A. Cenetti, et al. "Superoxide anion production by circulating polymorphonuclear leucocytes in rheumatoid arthritis," Clinical rheumatology, 9, No. 1, 1990, pp. 51-55, Italy.
D. E. Auer, et al. "Superoxide production by stimulated equine polymorphonuclear leukocytes inhibition by anti-inflammatory drugs," J. vet. Pharmacol. Therap., 13, 1990, pp. 59-66, Australia.
Jeffrey R. Kanofsky "Singlet Oxygen Production by Biological Systems," Chem.-Biol. Interactions, 70, 1989, pp. 1-28, Ireland.
Mueller Richard A.
Partis Richard A.
Cintins Marianne M.
G. D. Searle & Co.
Hastreiter Roberta L.
Scalzo Catherine
Williams Roger A.
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