Irreversible inhibitors of adenosine receptors

Details Irreversible inhibitors of adenosine receptors Irreversible inhibitors of adenosine receptors

1992-02-18

1994-03-29

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514261, 514265, 514266, 544267, 544277, 544269, A61K 3152, A01N 4390, C07D47306, C07D47334

Patent

active

052985083

ABSTRACT:
Irreversible ligands for adenosine receptors are derived from agonist and antagonist functionalized congeners which contain electrophilic acylating and alkylating groups for reaction at nucleophilic residues of adenosine receptors. The ligands are based on 8-aryl-substituted xanthines as antagonists and on N.sup.6 -substituted adenosine as agonists, wherein the electrophlic group may be, for example, isothiocyanate and N-hydroxysuccinimide esters.

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