Human galactosyltransferases

Details Human galactosyltransferases Human galactosyltransferases

1998-04-03

1999-09-21

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435320, 435325, 435455, 536 231, C12C 168, C12N 1500, C12N 500, C07H 2102

Patent

active

059552824

ABSTRACT:
The invention provides human galactosyltransferases (HUGA) and polynucleotides which identify and encode HUGA. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HUGA.

REFERENCES:
Goode, S. et al., "The neurogenic genes egghead and brainiac define a novel signaling pathway essential for epithelial morphogenesis during Drosophila oogenesis", Development, 122: 3863-3879 (1996).
Lodish, H. et al., Molecular Cell Biology, Scientific American Books, New York, NY., pp. 196-197, 623-624, 1167-1172 (1995).
Gumbiner, B.M., "Epithelial Morphogenesis", Cell, 69: 385-387 (1992).
Watson, K.L. et al., "Drosophila in cancer research: the first fifty tumor suppersor genes", J. Cell Sci. Suppl., 18: 19-33 (1994).
Morisato, D. and K.V. Anderson, "Signaling Pathways That Establish the Dorsal-Ventral Pattern of the Drosophila Embryo", Annu. Rev. Genetics, 29: 371-399 (1995).
Goode, S. et al., "The neurogenic Iocus brainiac cooperates with the Drosophila EGF receptor to establish the ovarian follicle and to determine its dorsal-ventral polarity", Development, 116: 177-192 (1992).
Goode, S. et al., "brainiac Encodes a Novel, Putative Secreted Protein That Cooperates with Grk TGF.alpha. in the Genesis of the Follicular Epithelium", Developmental Biol., 178: 35-50 (1996).
Yuan, Y.P. et al., "Secreted Fringe-like Signaling Molecules May Be Glycosyltransferases", Cell, 89: 9-11 (1997).
Hennet, et al., "Genomic Cloning and Expression of Three Murine UDP-galactose: .beta.-N-Acetyglucosamine .beta.1,3-Galactosyltransferase Genes", J. Biol. Chem., 273: 58-65 (1998).
Kolbinger, F. et al., "Cloning of a Human UDP-galactose:2-Acetamido-2-deoxy-D-glucose 3.beta.-Galactosyltransferase Catalyzing the Formation of Type 1 Chains", J. Biol. Chem., 273: 433-440 (1998).
Yadav, S. and K. Brew, "Identification of a Region of UDP-galactose: N-Acetylglucosamine .beta.4-Galactosyltransferase Involved in UDP-galactose Binding by Differential Labeling", J. Biol Chem., 265: 14163-14169 (1990).
Yadav, S.P. and K. Brew, "Structure and Function in Galactosyltransferase", J. Biol. Chem., 266: 698-703 (1991).
Shaper, N.L. et al., "The Chicken Genome Contains Two Functional Nonallelic .beta.1,4-Galactosyltransferase Genes", J. Biol. Chem., 272: 31389-31399 (1997).
Shur, B.D., "Glycosyltransferases as cell adhesion molecules", Curr. Opin. Cell Biol., 5: 854-863 (1993).
Uejima, T. et al., "Compementary DNA Cloning for Galacosyltransferase Associated with Tumor and Determination of Antifenic Epitopes Recognized by Specific Monoclonal Antibodies", Cancer Res., 52: 6158-6163 (1992).
Paulson, J.C. and K.J. Colley, "Glycosyltransferases", J. Biol. Chem., 264: 17615-17618 (1989).
Etienne-Decerf, J. et al., "Elevated anti-.alpha.-galactosyl antibody titres. A Marker of progression in autoimmune thyroid disorders and in endocrine ophthalmopathy?", Endocrinol., 115: 67-74 (1987).
Hillier et al., Genbank Accession Number H20623, Jul. 3, 1995.
Hillier et al. Genbank Accession Number N63041, Mar. 1, 1996.

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