Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-06-05
1999-09-21
Elliott, George C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 43525233, 4353201, 536 235, 536 2431, 536 2433, C07H 2104, C12N 121, C12N 1570, C12Q 168
Patent
active
059552786
ABSTRACT:
The invention provides a human translational regulator (TRANAC) and polynucleotides which identify and encode TRANAC. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of TRANAC.
REFERENCES:
Morley, S.J. and Traugh, J.A. "Differential Stimulation of Phosphorylation of Intitiation Factors eIF-4F, eIF-4B, EIF-3, and Ribosomal Protein S6 by Insulin and Phorbol Esters" J.Biol.Chem. (1990) 265:10611-10616.
Lazaris-Karatzas, A. et al., "Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap" Nature (1990) 345:544-547.
Hu, C. et al., "Molecular cloning and tissue distribution of PHAS-I, an Intracellular target for insulin and growth factors" Proc.Natl.Acad.Sci.USA (1994) 91:3730-3734.
Lin, T. and Lawrence, J.C. Jr. "Control of the Translational Regulators PHAS-I and PHAS-II by Insulin and cAMP in 3T3-L1 Adiopocytes" J.Biol.Chem. (1996) 271:30199-30204. (GI 1658516; GI 1658515).
Hawkins Phillip R.
Hillman Jennifer L.
Billings Lucy J.
Elliott George C.
Incyte Pharmaceuticals Inc.
Mohan-Peterson Sheela
Price Leanne C.
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