Anti-ovulatory decapeptides

Details Anti-ovulatory decapeptides Anti-ovulatory decapeptides

1979-12-17

1981-03-03

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

2601125LH, C08L 3700, C07C10352

Patent

active

042539978

ABSTRACT:
The compounds D-p-Glu-D-Phe-D-Nal(1)-L-Ser-L-Tyr-X-L-Leu-L-Arg-L-Pro-Gly-NH.sub.2 where X is D-Nal(1), D-Trp, D-Phe, D-Tyr, D-Lys, D-Met, D-Ala or D-Pgl and pharmaceutically acceptable salts thereof exhibit antiovulatory activity in female mammals and are useful contraceptive agents.

REFERENCES:
Matsuo, et al., Biochem. and Biophys. Res. Commun., 43, (1971), 1334-1339.
Rees, et al., J. of Med. Chem., (1974), vol. 17, 1016-1019.
Beattie, et al., J. of Med. Chem., 18, (1975), 1247-1250.
Rinier, et al., Life Sciences, 23, (1978), 869-876.
Yabe, et al., Chem. Pharm. Bull., 21, (1976), 3149-3157.

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