NMDA-blocking pharmaceuticals

Details NMDA-blocking pharmaceuticals NMDA-blocking pharmaceuticals

1994-02-07

1996-05-28

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3135

Patent

active

055212158

ABSTRACT:
Pharmaceutical compositions are described for preventing neurotoxicity, crising as active ingredient the stereospecific (+) enantiomer, having (3S,4S) configuration of .DELTA..sup.6 tetrahydrocannabinol type compounds. The compositions are particularly effective in alleviating and even preventing neurotoxicity due to acute injuries to the central nervous system, including mechanical trauma, compromised or reduced blood supply as may occur in cardiac arrest or stroke, or poisonings. They are also effective in the treatment of certain chronic degenerative diseases characterized by gradual neuronal loss.

REFERENCES:
patent: 4133819 (1979-01-01), Johnson
patent: 4179517 (1979-12-01), Mechoulam et al.
patent: 4209520 (1980-06-01), Johnson
patent: 4876276 (1989-10-01), Mechoulam et al.
Mechoulam et al., Tetrahedron Asymmetry 1:315-319 (1990).
Choi, Neuron 1:623-624 (1988).
Kloog et al., Biochemistry 27:843-848 (1988).
Mechoulam et al., Experientia 44:762-764 (1988).
Feigenbaum et al., Pharmacol. Biochem. Behav. 16:235-240 (1982).

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