Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2

Details Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2

1994-08-29

1996-05-28

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514338, 514359, 514365, 514367, 514372, 514373, 514374, 514412, 548153, 548181, 548207, 548235, 548260, 548412, 548414, 548453, 549 50, 549 51, 549 52, 549 58, 549 59, 549396, 549469, A61K 3138, C07D33300, C07D33352

Patent

active

055212131

ABSTRACT:
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

REFERENCES:
Valadovska et al., CA102:39239, 1984.
Ivanov et al., CA70:3595, 1966.
Chem. Abstracts 44:2510b, 1950.
Chem. Ber. (1982), 115(12), 3719-36.
J. Chem. Soc., Perkin Trans. 1 (1972), (2), 218-21.
Chem. Abstracts 113 (22):201340m CA.

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