Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-09-13
1996-05-28
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514269, 544242, 544311, 544309, 544310, A61K 31505, C07D23926
Patent
active
055211895
ABSTRACT:
The present invention provides methods for treating Pneumocystis carinii pneumonia and Giardia lamblia in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1## wherein: X and Y are located in the para or meta positions and are selected from the group consisting of H, loweralkyl, loweralkoxy, and ##STR2## wherein: each R.sub.1 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.1 groups together represent C.sub.2 -C.sub.10 alkyl, hydroxyalkyl, or alkylene, or two R.sub.1 groups together represent ##STR3## wherein m is from 1-3 and R.sub.7 is H or --CONHCR.sub.8 NR.sub.9 R.sub.10.
REFERENCES:
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Das, B. P., et al., Synthesis and Antiprotozoal Activity of 2,5-Bis(4-guanylphenyl)furans, J. Medicinal Chemistry 20:531 (1977).
Das, B. P., et al., Synthesis and Antiprotozoal Activity of 2,5-Bis(4-guanylphenyl)thiophenes and -pyrroles, J. Medicinal Chemistry 20:1219 (1977).
Das, B. P., et al., Synthesis and Antitrypanosomal Activity of Some Bis(4-guanylphenyl)Five- and Six-Membered Ring Heterocycles, J. Medicinal Chemistry 23:578 (1980).
Dykstra, C., et al, Synthesis and Characterization of a Novel Series of Aromatic Dicationic Furans With DNA-Specific Fluorescence Properties, pp. 1-7, (1994).
Rooney et al., Human Cytogenetics: A Practical Approach, ed., IRL Press, Oxford University Press, selected pages, 1993.
Boykin David W.
Dykstra Christine C.
Hall James E.
Kumar Arvind
Tidwell Richard R.
Gupta Yogendra N.
The University of NC at CH
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