Substituted pyrazoles for the treatment of inflammation

Details Substituted pyrazoles for the treatment of inflammation Substituted pyrazoles for the treatment of inflammation

1995-09-28

1996-12-03

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544140, 544371, 546211, 546256, 5462754, 5462761, 5462704, 5462714, 5483657, A61K 31415, C07D40306

Patent

active

055809855

ABSTRACT:
A class of pyrazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein R.sup.1 is selected from hydrido, alkyl, alkenyl, aralkyl, alkynyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl, arylaminocarbonylalkyl, heterocyciicalkyl, and alkoxycarbonylalkyl; wherein R.sup.3 is aryl substituted at a substitutable position with halo; wherein R.sup.4 is selected from hydrido and haloalkyl; and wherein R.sup.5 is selected from alkyl and amino; or a pharmaceutically-acceptable salt or prodrug thereof.

REFERENCES:
patent: 3254093 (1966-05-01), Huisgen et al.
patent: 3984431 (1976-10-01), Gu er emy et al.
patent: 5134142 (1993-02-01), Matsuo et al.
T. Hla and K. Nielson, Proc. Natl. Acad. Sci, USA, 89, 7384 (1992).
J. Masferrer, et al, Proc. Natl. Acad. Sci, USA, 89, 3917 (1992).
E. Meade et al, J. Biol. Chem., 268, 6610 (1993).
N. Futaki et al, Prostaglandins, 47, 55 (1994).

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