Anti-adhesion films and compositions for medical use

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...

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523105, 523113, 602 50, 602 52, C08G 6348, C08G 6391, A61F 200

Patent

active

055809235

ABSTRACT:
Anti-adhesion films useful for the prevention of surgical adhesions are disclosed. These films comprise substrate materials (such as collagen) and hetero-bifunctional anti-adhesion binding agents, wherein the substrate material is covalently linked to receptive tissue within the body of a patient via the binding agent. Preferred binding agents comprise substrate-reactive and tissue-selective functional groups. Anti-adhesion compositions useful for the formation of such films are also disclosed.

REFERENCES:
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T. Tulandi, M.D., "Effects of Fibrin Sealant on Tubal Anastomosis and Adhesion Formation", Fertility and Sterility, vol. 56, No. 1, pp. 136 138 (1991).
N. Fleisher et al., "Regeneration of Lost Attachment Apparatus in the Dog Using Polygalactin-910", J. Dent. Res., 66 Spec. Issue Mar., vol. 281, Abstract 1393 (1987).
K. Pagidas, M.D. et al, "Effects of Ringer's Lactate, Interceed (TC7) and Gore-Tex Surgical Membrane on Postsurgical Adhesion Formation", Fertility and Sterility, vol. 57, No. 1, pp. 199-201 (1992).
A. Steinleitner, M.D. et al, "Poloxamer 407 as an Intraperitoneal Barrier Material for the Prevention of Postsurgical Adhesion Formation and Reformation in Rodent Models for Reproductive Surgery", Obstetrics and Gynecology, 77:48-52 (1991).

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