Method for producing oriented connective tissue cells in a ligam

Details Method for producing oriented connective tissue cells in a ligam Method for producing oriented connective tissue cells in a ligam

1995-01-09

1996-05-28

Naff, David M.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435174, 43524023, 623 1, 623 13, 623 16, A61F 206, A61F 208, A61F 210, C12N 502

Patent

active

055210872

ABSTRACT:
The present invention pertains to an oriented tissue-equivalent formed by contracting a collagen solution with connective tissue cells. In the method of the present invention, the contraction of collagen fibrils by the connective tissue cells is restrained along an axis of cell alignment defined by at least two structural members within the gel, whereby the connective tissue cells align along the axis thereby producing an oriented tissue-equivalent. In a preferred embodiment fibroblast cells are used to contract a collagen gel to form connective tissue into a ligament configuration.

REFERENCES:
patent: 4458678 (1984-07-01), Yannas et al.
patent: 4485096 (1984-11-01), Bell
patent: 4485097 (1984-11-01), Bell
patent: 4539716 (1985-09-01), Bell
patent: 4546500 (1985-10-01), Bell
Bell, E., et al., PNAS USA, 76(B): 1274-1278 (1979).
Weinberg, C. G., and Bell, E., J. Cell Physiol. 122: 410-414 (1985).
Ehrlich, H. T., J. Cell Sci., 82: 281-294 (1986).
Weinberg, C. B. and Bell, E., Science, 231: 397-400 (1986).
Aggarwal, A., A Syngeneic Ligament Equivalent, Phase I: Mechanical . . . Lattice, S. B., Thesis M.I.T.

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