Process for the preparation of 5-(2',4'difluorophenyl)-salicylic

Details Process for the preparation of 5-(2',4'difluorophenyl)-salicylic Process for the preparation of 5-(2',4'difluorophenyl)-salicylic

1992-07-29

1993-02-02

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 6976

Patent

active

051839350

ABSTRACT:
A crystallization process of crude 5-(2',4'-difluorophenyl)-salicylic acid from a mixture of an aromatic hydrocarbon and an aliphatic ketone for preparing 5-(2',4'-difluorophenyl)-salicylic acid in form II substantially pure is described.

REFERENCES:
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patent: 4847442 (1989-07-01), Nalelwajek
Yin, M. et al. Yiyao Gongye, (9) 26-8 1984.
Shen T. Y. et al. INSERM Symp.; 23 (Platelet-Act. Factor Struct. Relat. Ether-Lipids 167-76 1983.
The Merck Index, XI ed., No., 3130. p. 495, 1989. Susan Budavari, ed. "2,4-Difluoroaniline."
Analytical Profiles of Drug Substances, pp. 491-526, 1985. Meredith L. Cotton and Robert A. Hux, "Diflunisal."
British Pharmacopoeia, pp. 191-192, 1988. "Diflunisal."

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