Efficient method for preparation of prolonged release liposome-b

Details Efficient method for preparation of prolonged release liposome-b Efficient method for preparation of prolonged release liposome-b

1989-05-12

1991-06-11

Page, Thurman

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 11, 424 9, 264 46, A61K 3722

Patent

active

050230875

ABSTRACT:
A method for selectively controlling the rate of release of a liposome-entrapped compound from an intramuscular or subcutaneous injection site. The method includes selecting the average size, amount, and lipid composition of liposomes injected into the site to produce a desired half-life of release of the compound. A preferred composition used in practicing the invention includes an aqueous suspension of liposomes containing the compound in entrapped form, and having average particle sizes less than about 0.2 microns, and large amount of larger empty lipsomes present in an amount effective to increase the half-life of release of the compound from the injection site to a desired half-life between about 1-14 days.

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