Surgery – Truss – Pad
Patent
1994-02-24
1996-05-28
Zele, Krista M.
Surgery
Truss
Pad
128659, 2503361, 25037008, A61B 600
Patent
active
055201822
ABSTRACT:
A two- and three-dimensional autoradiographical imaging system is provided which includes a charge coupled device for detecting the emission of radioactively labeled substances from materials such as tissue samples, brains of humans or animals, or substances used in electrophoresis applications. In a first aspect, a radioactively labeled substance is included in a tissue sample. The tissue sample is sequentially imaged by a charge coupled device and a sectioning tool such as a microtome to produce a plurality of two-dimensional images. A three-dimensional image of the tissue sample is generated by further processing of the plurality of two-dimensional images derived from the charge coupled device. In a further aspect of the invention, a charge coupled device is utilized to provide realtime imaging of metabolic or physiological parameters involved in brain activity. A charge coupled device is positioned adjacent a portion of brain tissue desired to be examined, the brain tissue having a radioactively labeled substance therein for detection by the charge coupled device. A two-dimensional realtime image is produced using the charge coupled device for use in clinical or behavioral studies. In another aspect of the invention, a charge coupled device is utilized in electrophoresis applications to monitor radioactively labeled or tagged substances during electrophoresis. In this application, use of the charge coupled device permits small sample volumes of material to be used during electrophoresis, as well as automatic end point detection.
REFERENCES:
patent: 3678148 (1972-07-01), Caiola
patent: 3876882 (1975-04-01), Todd
patent: 3958558 (1976-05-01), Dunphy
patent: 4015592 (1977-04-01), Bradley-Moore
patent: 4114606 (1978-09-01), Seylar
patent: 4224303 (1980-09-01), Shaw
patent: 4377958 (1983-03-01), Leighton
patent: 4476231 (1984-10-01), Deindoerfer et al.
patent: 4517976 (1985-05-01), Murakoshi et al.
patent: 4595014 (1986-06-01), Barrett et al.
patent: 4608992 (1986-09-01), Hakim
patent: 4611247 (1986-09-01), Ishida et al.
patent: 4622954 (1986-11-01), Arakawa et al.
patent: 4623288 (1986-11-01), Brunelli et al.
patent: 4636380 (1987-01-01), Wong
patent: 4833327 (1989-05-01), Hart
patent: 4889991 (1989-12-01), Ramsey et al.
patent: 4893013 (1990-01-01), Denen et al.
patent: 4976266 (1990-12-01), Huffman et al.
patent: 4995396 (1991-02-01), Inaba et al.
patent: 5005195 (1991-04-01), Lanza et al.
patent: 5014708 (1991-05-01), Hayashi et al.
patent: 5028793 (1991-07-01), Lindmayer et al.
patent: 5070878 (1991-12-01), Denen
patent: 5103823 (1992-04-01), Acharya et al.
patent: 5119818 (1992-06-01), Carroll et al.
patent: 5151598 (1992-09-01), Denen
patent: 5301671 (1994-04-01), Leighton et al.
Stephen B. Leighton, "SEM Images of Block Faces, Cut By a Miniature Microtome within the SEM--A Technical Note", Scanning Electron Microscopy, (1981), pp. 73-76.
Stephen B. Leighton, "A Miniature Microtome for Use Inside a Scanning Electron Microscope", Advances in Bioengineering, (1981), pp. 45 and 46.
Stephen B. Leighton, "Oxygen Plasma Etching of Entire Block Faces Improves the Resolution and Usefulness of Serial Scanning Electron Microscopic Images", Scanning Electron Microscopy, (1983), pp. 1877-1885.
Texas Instruments, "Solid State Image Sensor", (Oct. 1989), p. 1.
Charon et al., "A High Resolution .beta..sup.- Detector", Nuclear Instruments and Methods In Physics Research, A273 (1988), pp. 748-753.
Leighton Stephen B.
Olds James L.
The United States of America as represented by the Department of
Zele Krista M.
LandOfFree
Method and apparatus for producing an image of a substance using does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for producing an image of a substance using, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for producing an image of a substance using will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-780327