1H-imidazole derivative compounds and pharmaceutical composition

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

548336, A61K 31415, A61K 3138, C07D40312

Patent

active

051359430

ABSTRACT:
The 1H-imidazole derivative compound of formula I: ##STR1## and its nontoxic addition salts, particularly the nitrate addition salt, are more effective as antimycotic agents and are unexpectedly safer than the corresponding prior art compounds, especially the compound in which the sulfur atom of the benzothiophene ring of the above compound is replaced by an oxygen atom. Pharmaceutical compositions containing an effective amount of the compound of formula I, e.g. 1 to 5% by weight, in a pharmaceutical carrier are safer, more effective, and, in some cases, more reliable with fewer side effects than currently used antimycotic preparations.

REFERENCES:
patent: 4272545 (1981-06-01), Walker
patent: 4402968 (1983-09-01), Martin
patent: 4410539 (1983-10-01), Cross et al.
patent: 4463011 (1984-07-01), Ogata et al.
patent: 4496572 (1985-01-01), Cross et al.
patent: 4500536 (1985-02-01), Yoshida et al.

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