Substituted derivatives of 3-amino-2-hydroxypropionic acid as in

Details Substituted derivatives of 3-amino-2-hydroxypropionic acid as in Substituted derivatives of 3-amino-2-hydroxypropionic acid as in

1988-05-23

1992-08-04

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

548344, A61K 31415, C07D23364

Patent

active

051359146

ABSTRACT:
Novel substituted derivatives of 3-amino-2-hydroxypropionic acid are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as renin inhibitors and thus useful in controlling hypertension, hyperaldosteronism and congestive heart failure as well as diagnostic agents.

REFERENCES:
patent: 4814342 (1989-03-01), Hoover
Bolis et al, Renin Inhibitors, J Med Chem 1987, 30 1729-1737.
Haber et al, Renin Inhibitors, J Cardio Pharm 1987, 10 (Supp 7) 554-558.
Plattner et al, Renin Inhibitors, J Med Chem 1988, 31 2277-2288.
Denkewalker et al, Progress in Drug Research, vol. 10 1966 510-512.
Medicinal Chemistry, A. Burger 1960 565-601.
Boger et al., Hypertension vol. 15, No. 6, Part 2, pp. 835-840 (Jun. 1990).
Webb et al., J. Cardiovascular Pharm., vol. 10 (Suppl. 7), pp. 569-574 (1987).
Zhou et al., Clin. Pharm. 2nd Therapeutics, vol. 47, p. 141 (1990).
van der Meiracker, British Med. J., vol. 301, pp. 205-210 (Jul. 1990).

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