Methods and compositions for inducing production of stress prote

Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof

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424641, 424650, 514493, 514494, A01N 5916, A01N 5504, A01N 5502

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active

059551119

ABSTRACT:
The present invention relates to compositions and methods of production of stress proteins using tin or zinc metal ions. The invention relates to methods of protecting a mammal against injury caused by a noxious condition by administering to the mammal tin or zinc metal ions in sufficient quantity and under appropriate conditions to induce production of stress proteins at sufficient levels to provide partial or complete protection against injury caused by a noxious condition which occurs subsequent to stress protein production. The invention also relates to methods of inducing stress protein production in a mammal by administering tin or zinc metal ions in sufficient quantity and under appropriate conditions to induce production of stress proteins to protect the mammal against injury caused by a noxious condition. The invention also relates to compositions comprising tin or zinc metals, stress proteins, and/or agents which enhance or prolong the activity of stress proteins or which aid in the uptake of the heavy metal ions into the tissue.

REFERENCES:
patent: 5389383 (1995-02-01), Huth
patent: 5614553 (1997-03-01), Ashmead et al.
patent: 5618838 (1997-04-01), Chevion et al.
C.G. Taylor et al., "Comparison of Zn and Vitamin E for Protection Against Hyperoxia-Induced Lung Damage," Free Radical Biology & Medicine, 22(3):543-550 (1997).
D. Willis et al., "Heme Oxygenase: A Novel Target for the Modulation of the Inflammatory Response," Nature Medicine, 2(1):87-90 (Jan. 1996).
Michal Laniado-Schwartzman et al., "Heme Oxygenase Induction with Attenuation of Experimentally Induced Corneal Inflammation," Biochemical Pharmacology, 53:1069-1075 (1997).
G. Russotti et al., "Induction of Tolerance to Hypothermia by Previous Heat Shock Using Human Fibroblasts in Culture," Cryobiology, 33:567-580 (1996).
Kadoya, Chitoshi et al., "Preischemic But Not Postischemic Zinc Protoporphyrin Treatment Reduces Infarct Size and Edema Accumulation After Temporary Focal Cerebral Ischemia in Rats," Stroke, vol. 26, No. 6:1035-1038 (1995).
Cornwall, Mark W., "Zinc Iontophoresis to Treat Ischemic Skin Ulcers," Physical Therapy, vol. 61, No. 3:359-360 (1981).
Bianco, Jesus A., et al., "Technetium-99m(Sn.sup.2+) Pyrophosphate in Ischemic and Infarcted Dog Myocardium in Early Stages of Acute Coronary Occlusion: Histochemical and Tissue-Counting Comparisons," J. Nucl. Med., vol. 24, No. 6:485-491 (1983).
Babenko, G.A. et al., "Use of Zinc Valerate in the Complex Treatment of Ischemic Disease," Vracebnoe Delo vol. 8, pp:21-23 (1971).
Duquesnoy, Rene J., "Stress Protein Research in Transplantation," Cell Stress & Chaperones, vol. 1, No. 1:2-4 (1996).
Perdrizet, George A., "Heat Shock and Tissue Protection," New Horizons, vol. 3, No. 2:312-320 (1995).
Perdrizet, George A., "The Heat Shock Response and Organ Transplantation," Transplantation Reviews, vol. 10, No. 2:78-98 (1996).
Perdrizet, George A. et al., "Heat Shock Protects Pig Kidneys Against Warm Ischemic Injury," Transplantation Proceedings, vol. 22, No. 2:460-461 (1990).
Perdrizet, George A. et al., "Heat Shock and Recovery Protects Renal Allografts From Warm Ischemic Injury and Enhances HSP72 Production," Transplantation Proceedings, vol. 25, No. 1:1670-1673 (1993).
Perdrizet, George A. et al., "Heat Shock and Recovery Protects Pancreatic Islets From Warm Ischemic Injury," Transplantation Proceedings, vol. 26, No. 6:3477-3478 (1994).
Chatson, George et al., "Heat Shock Protects Kidneys Against Warm Ischemic Injury," Current Surgery, vol. 47, No. 6:420-423 (1990).
Wang, Bernadette, H. and Udelsman, Robert, "Improved Musculocutaneous Flap Survival with Induction of Heat Shock Protein," Abstract, Cold Spring Harbor Laboratory Symposium on Molecular Chaperones and the Heat Shock Response, Cold Spring Harbor, New York, May 1-5, 1996, p.343.
Hilden, Shirley, "Stress Proteins in Renal Ischemia," eds. John J. Lemasters, Constance Oliver, Cell Biology of Trauma Chapter 15, 227-250 (1995).
Perdrizet, George A. et al., "Stress Conditioning: A Novel Approach to Organ Preservation," Current Surgery, vol. 46, No. 1:23-26 (1989).
Neil, Teresa K. et al., "Differential Heme Oxygenase Induction by Stannous and Stannic Ions in the Heart," J. of Cell. Biol., vol. 57:409-414 (1995).
Levinson, Warren et al., "Metal Binding Drugs Induce Synthesis of Four Proteins in Normal Cells," Bio. Trace Element Res., vol. 1:15-23 (1979).
Welch, William J. et al., "Biochemical Characterization of the Mammalian Stress Proteins and Identification of Two Stress Proteins as Glucose- and Ca.sup.2+ - Ionophore-regulated Proteins," J. Bio. Chem., vol. 258, No. 11:7102-7111 (1983).
Young, Richard A. and Elliott, Timothy J., "Stress Proteins, Infection, and Immune Surveillance," Cell, vol. 59:5-8 (1989).
Koenig, William J. et al., "Improving Acute Skin-Flap Survival Through Stress Conditioning Using Heat Shock and Recovery," Plastic and Reconstructive Surgery, vol. 90, No. 4:659-664 (1992).
Hotchkiss, Richard et al., "Hyperthermia protects mice against the lethal effects of endotoxin," Am. J. Physiol., 265 (Regulatory Integrative Comp. Physiol. 34):R1447-R1457 (1993).
Conners, Michael S. et al., "A Closed Eye Contact Lens Model of Corneal Inflammation," Investigative Ophthalmology & Visual Science, vol. 36(5):841-850 (1995).
Perdrizet, George A. et al., "Surgical Stress and the Heat Shock Response," Abstract, Cold Spring Harbor Laboratory Symposium on Molecular Chaperones and the Heat Shock Response, Cold Spring Harbor, New York, May 1-5, 1996, p. 240.
Perdrizet, George A. et al., "The Heat Shock Response Protects Organs from Preservation Injury," Poster, IMEDEX 4th Basic Sciences Symposium of the Transplantation Society, Noordwijkerhout, The Netherlands, Sep. 17-20, 1995.
Neil, Teresa, K. et al., "Modulation of Corneal Heme Oxygenase Expression by Oxidative Stress Agents," Journal of Ocular Pharmacy and Therapeutics, vol. 11, No. 3: 455-468 (1995).
Abraham, N.G. et al., "Transfection of the Human Heme Oxygenase Gene into Rabbit Coronary Microvessel Endothelial Cells: Protective Effect Against Heme and Hemoglobin Toxicity," Proc. Natl. Acad. Sci. USA, vol. 92, 6798-6802 (1995).
Mitani, Kinuko et al., "The Role of Inorganic Metals and Metalloporphyrins in the Induction of Haem Oxygenase and Heat-shock Protein 70 in the Human Hepatoma Cells," Biochem. J. (England) vol. 290:819-825 (1993).
Levere, R.D., et al., "Amelioration of Hemorrhage Induced Brain Injury by Tin-Protoporphyrin," J. Cell. Biol. 107 (6 Part 3): 726a (1988) Abstract 4116.
DaSilva, Jean-Louis et al., "Dual Role of Heme Oxygenase in Epithelial Cell Injury: Contrasting Effects of Short-term and Long-term Exposure to Oxidant Stress," J Lab Clin Med vol. 128, No. 3:290-296 (1996).
Levere, Richard, D. et al., "Role of Heme Oxygenase in Heme-Mediated Inhibition of Rat Brain Na.sup.+ -K.sup.+ -ATPase: Protection by Tin-Protoporphyrin," Neurochemical Research, vol. 14, No. 9:861-864 (1989).
DaSilva, Jean-Louis, et al., "Tin-Mediated Heme Oxygenase Gene Activation and Cytochrome P450 Arachidonate Hydroxylase Inhibition in Spontaneously Hypertensive Rats," The American Journal of the Medical Sciences, vol. 307, No. 3: 173-181 (1994).
Lutton, John D. et al., "Coexpression of Erythropoietin and Heme Oxygenase Genes in Hep3B Cells," Hepatology, vol. 17, No. 5:861-868 (1993).
Levere, R.D. et al., "Role of Heme Oxygenase in Hemoglobin-Mediated Inhibition of Brain Na.sup.+ -K.sup.+ -ATPase: Protection by Tin-Protoporphyrin", Clin. Res. vol. 36, No. 3:549a (1988) Abstract.
Stoltz, R. et al., "Heme Oxygenase May be an Important Protector Against Oxidative Stress-Associated Rise in ICAM Expression in Endothelial Cells," Clin. Res. Mtg., J. of Invest. Med., vol. 43, No. 2(Suppl. 2):375A (1995).
Abraham, N.G. et al., "Transfection of the Human Heme Oxgenase Gene into Coronary Endothelial Cells Protects Against Heme/Hemoglobin Toxicity," Clin. Res. Mtg., J. of Invest Med., vol. 43, No. 2(Suppl. 2):215A (1995).
Neil, T.K. et al., "Corneal Epithelial Heme Oxygenase: A Potential Protective Enzyme Against Oxidative Stress-Induced Injury," Invest. Opthal. & Vis.

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