Linking agents and methods

Details Linking agents and methods Linking agents and methods

1988-02-03

1990-11-13

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

540471, C08B 3700

Patent

active

049703030

ABSTRACT:
Compounds containing carbohydrate moieties or carboxyl groups are linked to either compounds containing thiol moieties or electron-deficient moieties by the use of linking agents of the formula ##STR1## in which R.sup.1 is NH.sub.2 -- or NH.sub.2 --NH--; R.sup.2 is --NH--C(O)--, --C(O)--NH--, or --C(O)--; R.sup.3 is C.sub.1 -C.sub.10 alkylene, C.sub.5 -C.sub.7 cyclic alkylene, arylene, phenyl-substituted C.sub.1 -C.sub.10 alkylene, benzyl-substituted C.sub.1 -C.sub.10 alkylene, or amino-substituted C.sub.1 -C.sub.10 alkylene; R.sup.4 is H, acetyl, ##STR2## where R.sup.5 is C.sub.1 -C.sub.5 alkyl; m is zero or 1; and n is zero or 1.

REFERENCES:
patent: 4671958 (1987-06-01), Rodwell et al.
Blair et al., "Linkage of Cytotoxic Agents to Immunoglobulins," J. Immun. Methods, 59 (1983), 129-143.

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