Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-01-13
1998-10-06
Railey, II, Johnny F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
4242781, 435975, 514 44, 514615, 514818, A61K 4505, A61K 4800, A61K 3100
Patent
active
058176373
ABSTRACT:
Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
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Wang Bin
Weiner David B.
Williams William V.
Railey II Johnny F.
The Trustees of the University of Pennsylvania
The Wistar Institute
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