Process for preparation of dipeptides

Details Process for preparation of dipeptides Process for preparation of dipeptides

1989-09-14

1992-09-01

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

544385, 560 37, 560 40, 560 42, 564168, C07C12600

Patent

active

051440733

ABSTRACT:
Disclosed is a process for synthesis of a dipeptide such as N-acetyl-L-.alpha.-aspartyl-L-phenylalanine methyl ester wherein one amino acid serves as a chiral template which allows for synthesis of a second amino acid residue to form said dipeptide. The process involves several novel steps such as a nucleophile addition step. In addition, several novel intermediates are described.

REFERENCES:
patent: 4293648 (1981-10-01), Davino
patent: 4634790 (1987-01-01), Shinohara et al.
patent: 4668625 (1987-05-01), Cambiaghi et al.
patent: 4677220 (1987-06-01), Tou et al.
T. Kanmera et al., Int. J. Peptide Protein Res., 16, 280 (1980).
T. Kanmera et al., Tetrahedron Letters, 46, 4483 (1979).
Y. Hashimoto et al., Int. J. Peptide Protein Res., 21, 11 (1983).
S. Lee et al., Int. J. Peptide Protein Res., 13, 207 (1979).
H. Poisel et al., Chem. Ber., 106, 3408 (1973).
B. W. Bycroft et al., J.C.S. Chem. Comm., 616, 988, 989 (1975).
R. Brown et al., J. Org. Chem., 30, 277 (1965).
J. H. Birkinshaw et al., Biochem. J., 85, 523 (1962).
C. Shin et al., Heterocycles, 14 (11), 1767 (1980).
S. Akabori et al., Proc. Japan Acad., 27 (1), 7 (1951).
K. Blaha, Collection Czechoslov. Chem. Commun., 34, 4000 (1969).
C. Gallina et al., Tetrahedron Letters, 14, 1135 (1973).
N. Izumiya et al., J.A.C.S., 99:25 (1977).
T. Ueda et al., Bull. Chem. Soc. Jpn., 56, 568 (1983).
M. Bergmann et al., J. Biol. Chem., 535 (1944).
R. H. Mazur et al., Dev. Sweeteners, 1, 125 (1979).
J. D. Higginbotham et al., Sens. Prop. Foods, [Ind.-Univ. Co-op. Symp.] 129 (1976).

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