Process for the production of 3-oxocarboxylic acid esters

Details Process for the production of 3-oxocarboxylic acid esters Process for the production of 3-oxocarboxylic acid esters

1991-10-11

1992-09-01

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 9, 560125, 560126, 560174, C07C 6976

Patent

active

051440571

ABSTRACT:
3-Oxocarboxylic acid esters are produced by acylation of the magnesium enolates of acetoacetic acid esters with carboxylic acid chlorides and cleavage of the acetyl group from the acylacetoacetic acid esters formed as the intermediate product. The yields and purity of the products are considerably improved by adding a tertiary amine during the acylation.

REFERENCES:
C. R. Hauser and B. E. Hudson, Jr., "Organic Reactions", vol. 1 (1942) pp. 297 to 302.
G. Heese, "Methoden der organischen Chemie", [Methods of Organic Chemistry], vol. VI/1d, 4th Ed., (1978), p. 73.
B. M. Conrad, Justus Liebigs Ann. Chem., 188, (1877), pp. 296-274.
H. Henecka, "Methoden der organischen Chemie", 4th Ed., vol. VIII (1952), pp. 615 and 616.

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