Cytotoxic drug conjugates

Details Cytotoxic drug conjugates Cytotoxic drug conjugates

1991-02-15

1992-09-01

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303911, 5303915, 530409, 530410, 530807, 435188, C07K 1706, C07K 1714, C07K 1528

Patent

active

051440121

ABSTRACT:
Conjugates of antibodies and cytotoxic methotrexate drugs make use of liners between the drug and antibody which are simple organic groups, wherein the link to the antibody is an acyl group and the link to the drug is an alkylidene hydrazide.

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Lopes et al., Clinical Immunology (Proc. First IUIS Conference, Jul. 6-11, 1986) pp. 303-307 published 1987.
Oi et al., Biotech 4 (3):214-221 (1986).
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