Process for the preparation of 2-propyl-2-pentenoic acid and its

Details Process for the preparation of 2-propyl-2-pentenoic acid and its Process for the preparation of 2-propyl-2-pentenoic acid and its

1989-12-01

1990-10-23

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562532, 562535, C07C 6700

Patent

active

049654012

ABSTRACT:
The process for the preparation of the E isomers of the compounds of formula A: ##STR1## in which R.sub.1 is selected from H or C.sub.1 -C.sub.4 alkyl, comprises according to the invention the reaction of propionaldehyde with a phosphorus derivative of formula: ##STR2## in which R.sub.1 designates C.sub.1 -C.sub.4 alkyl and R.sub.2 is selected from C.sub.1 -C.sub.4 alkyl or phenyl, and, optionally, the hydrolysis of the compound of formula A in which R.sub.1 is alkyl in order to form the compounds of formula A in which R.sub.1 is H.
Pharmaceutical industry.

REFERENCES:
patent: 3177226 (1965-04-01), Stilz et al.
patent: 4591651 (1986-05-01), Delmas et al.
Beilsteins Handbuch der Organischen Chemie, 4ieme edition, vol. 2, 1920, Julius Springer Verlag, Berlin RAF, p. 452.
The Journal of Organic Chemistry, vol. 51, No. 9, 5/2/86, pp. 1735-1741, Amer. Chem. Society; J. A. Marshall et al.: "Condensation of Long-Chain Alpha-Phosphono Carboxylates with Aldehydes" p. 1736, Table 1; p. 1739, Table 3.
Chemische Berichte, vol. 99, No. 4, 1966, pp. 1198-1207, Verlag Chemie GmbH; H.-J. Bestmann et al.: "Eine Neue Synthese von Allen-Carbonsaureestern", p. 1203.
Bulletin of the Chemical Society of Japan, vol. 40, No. 12, Dec. 1967, pp. 2968-2970, K. Sasaki et al.: "Synthesis of Ethyl 5,9-Dimethyl-2,4,8-Decatrienoates and the Homologs".

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