Thiazolidine derivatives with anti-diabetic activity, their prep

Details Thiazolidine derivatives with anti-diabetic activity, their prep Thiazolidine derivatives with anti-diabetic activity, their prep

1991-01-24

1992-09-01

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548183, C07D41712, A01K 31425

Patent

active

051439301

ABSTRACT:
Compounds of formula (I): ##STR1## in which: A is a group of formula (II) or (III): ##STR2## W is methylene, carbonyl or >C.dbd.N--OV, where V is hydrogen, sulfo, acyl or alkyl; U is methylene, or W is absent and U is a carbon-carbon double bond between A and --CR.sup.1 (OH)--; R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each hydrogen or alkyl; Y.sup.1 and Y.sup.2 are each hydrogen or a hydroxy-protecting group; and n is 1, 2 or 3 and salts thereof have anti-diabetic activity in mammals. Methods of preparing them are also provided.

REFERENCES:
patent: 4572912 (1986-02-01), Yoshioka et al.
patent: 4873255 (1989-11-01), Yoshioka et al.
patent: 4933355 (1990-06-01), Yoshioka et al.

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