Dihydropyrimidine macrocyclic lactones useful as calcium antagon

Details Dihydropyrimidine macrocyclic lactones useful as calcium antagon Dihydropyrimidine macrocyclic lactones useful as calcium antagon

1990-07-25

1992-09-01

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142285, 5142328, 514267, 540600, 544 60, 544115, 544229, 544250, 544311, 556418, 556427, 568 62, 568 65, 568424, 568705, A61K 3155, A61K 31505, A61K 31535, C07D49704

Patent

active

051439158

ABSTRACT:
A compound of the formula ##STR1## (symbols defined in the specification), its 3,4-dihydropyrimidine tautomer form and pharmaceutically acceptable salts thereof have calcium entry blocking activity. A process of preparation, pharmaceutical composition and method of using the compound to reduce blood pressure are also provided.

REFERENCES:
patent: 4728652 (1988-03-01), Atwal
Rovnyak, G. et al., "Studies Directed Toward Ascertaining the Active Conformation of 1,4-Dihydropyridine Calcium Entry Blockers", Journal of Medicinal Chemistry, (1988), 936-944.
Seidel, W. et al., "Rigid Calcium Antagonists of the Nifedipine-Type: Geometric Requirements for the Dihydropyridine Receptor", QSAR Strategies Des. Bioact. Compd., Proc. Eur. Symp. Quant. Struct-Act. Relat., 5th, [54QWAZ], 1984, (Pub. 1985), 366-369 (Eng.).

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