Glucagon analogs with ASP.sup.9 replacements or deletions

Details Glucagon analogs with ASP.sup.9 replacements or deletions Glucagon analogs with ASP.sup.9 replacements or deletions

1991-12-16

1992-09-01

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530308, 530324, A61K 3728, C07K 710, C07K 734

Patent

active

051439026

ABSTRACT:
Glucagon analogs characterized principally by the removal of the 9-aspartic acid residue or its replacement with an amino acid residue other than an L- dibasic amino acid containing up to five carbon atoms with or without a histidine at the amino terminal are useful adjuncts to insulin therapy.

REFERENCES:
patent: 4879273 (1989-11-01), Merrifield
Jour. of Bio. Chem. vol. 259, issue on Jun. 10, pp. 7031-7037, 1984, Semisynthetic Derivatives of Glucagon, Flanders, et al.

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