Preparation for treating and preventing thromboses and thromboem

Details Preparation for treating and preventing thromboses and thromboem Preparation for treating and preventing thromboses and thromboem

1990-06-19

1992-09-01

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 12, 514 21, A61K 3700

Patent

active

051439018

ABSTRACT:
A preparation for the treatment and prevention of thromboses and thromboembolic complications is disclosed, which preparation has a content of protein S at a concentration at least 50 times that present in native plasma and is free from C4b-binding protein, optionally in combination with a content of activated protein C.

REFERENCES:
Kohler et al., "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", Nature, 256:495-497 (1975).
Schwarz, et al., "Plasma Protein S Deficiency in Familial Thrombiotic Disease", Blood, 64:1297-1300 (1984).
Griffin et al., "Plasma Protein S Deficiency and Thromboembolic Disease", Progress in Hematology, 15:39-49 (1987).
Laurell, "Electroimmuno Assay", Scand. J. Clin. Lab. Invest., 29:21-37 (1972).
Lowry et al., "Protein Measurement With The Folin Phenol Reagent", J. Biol. Chem., 193:265-275 (1951).
Laemmli, "Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4", Nature, 227:268-685 (1970).
Fareed et al., "A Modified Stasis Thrombosis Model to Study the Antithrombotic Actions of Heparin and Its Fractions" In: Seminars In Thrombosis And Hemostasis, II:155-175 (1985).
Wessler et al., "Biologic Assay of a Thrombosis-Inducing Activity In Human Serum", J. Appl. Physiol., 14:943-946 (1959).
1984. P. C. Comp et al., J. Clin. Invest. 74(6):2082-2088 Familial Protein S deficiency is associated with recurrent thrombosis.

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