Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1990-03-07
1992-09-01
Kepplinger, Esther L.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436528, 436527, 436807, 435 792, 435 794, 435 795, 435961, 435968, 435973, 530333, 530334, 530335, 530336, 530337, G01N 33543, C07K 104, B01J 1900
Patent
active
051438542
ABSTRACT:
Polypeptide arrays can be synthesized on a substrate by attaching photoremovable groups to the surface of a substrate, exposing selected regions of the substrate to light to activate those regions, attaching an amino acid monomer with a photoremovable group to the activated regions, and repeating the steps of activation and attachment until polypeptides of the desired length and sequences are synthesized. The resulting array can be used to determine which peptides on the array can bind to a receptor.
REFERENCES:
patent: 3849137 (1974-11-01), Barznski et al.
patent: 3862056 (1975-01-01), Hartman
patent: 4072576 (1978-02-01), Arwin et al.
patent: 4238757 (1980-12-01), Schenck
patent: 4314821 (1982-02-01), Rice
patent: 4339528 (1982-07-01), Goldman
patent: 4405771 (1983-09-01), Jagur
patent: 4444878 (1984-04-01), Paulus
patent: 4444892 (1984-04-01), Malmros
patent: 4517338 (1985-05-01), Urdea et al.
patent: 4542102 (1985-09-01), Dattagupta et al.
patent: 4555490 (1985-11-01), Merril
patent: 4562157 (1985-12-01), Lowe et al.
patent: 4569967 (1986-02-01), Kornreich et al.
patent: 4631211 (1986-12-01), Houghten
patent: 4637861 (1987-01-01), Krull et al.
patent: 4681859 (1987-07-01), Kramer
patent: 4704353 (1987-11-01), Humphries et al.
patent: 4713326 (1987-12-01), Dattagupta et al.
patent: 4713347 (1987-12-01), Mitchell et al.
patent: 4719615 (1988-01-01), Feyrer et al.
patent: 4722906 (1988-02-01), Guire
patent: 4762881 (1988-08-01), Kauer
patent: 4777019 (1988-10-01), Dandekar
patent: 4786684 (1988-11-01), Glass
patent: 4794150 (1988-12-01), Steel
patent: 4808508 (1989-02-01), Platzer
patent: 4822566 (1989-04-01), Newman
patent: 4833092 (1989-05-01), Geysen
patent: 4865990 (1989-09-01), Stead et al.
patent: 4946942 (1990-08-01), Fuller et al.
patent: 4973493 (1990-11-01), Guire
patent: 4979959 (1990-12-01), Guire
patent: 5026840 (1991-06-01), Dattagupta et al.
Furka et al., Int. J. Peptide Protein Res. (1991) 37:487-493.
Furka et al., Abstract No. 288 from Xth Int'l Symposium on Medicinal Chemistry, Budapest, Hungary, Aug. 15-19, 1988.
Furka et al., Abstract No. FR:013 from 14th Int'l Congress of Biochem., Prague, Czechoslovakia, Jul. 10-15, 1988.
Ohtsuka et al., Nucleic Acids Research (1974) 1:1351-1357.
Zehavi et al., J. Org. Chem. (1972) 37:2281-2285.
Second College Edition of the American Heritage Dictionary p. 522.
Frank et al., Tetrahedron (1988) 44:6031-6040.
Dulcey et al., Science (1991) 252:551-554.
BioRad Advertising Material, Catalog M, 1987, pp. 182.
Gazard et al., Polymer Engineering and Science (1980) 20:1069-1072.
Haridasan et al., Proc. Indian Natl. Sci. Acad., Part A (1987) 53:717-728.
Stuber et al., Int. J. Peptide Protein Res. (1983) 22:277-283.
Ajayaghosh et al., Proc. Indian Acad. Sci. (Chem. Sci.) (1988) 100:389-396.
Ajayaghosh et al., Tetrahedron Letters (1988) 44:6661-6666.
Ajayaghosh et al., J. Org. Chem. (1990) 55:2826-2829.
Purushothaman et al., Indian Journal of Chemistry (1990) 29B:18-21.
Ajayaghosh et al., Indian Journal of Chemistry (1988) 27B:1004-1008.
Bains et al., J. Theor. Biol. (1988) 135:303-307.
Lysov et al., Doklady Akademii Nauk SSSR (1988) 323:1508-1511.
Khrapko et al., FEBS Lett. (1989) 256:118-122.
Drmanac et al., Genomics (1989) 4:114-128.
Bains, Bio/Technology (1990) 8:1251-1256.
Pevzner, J. Biomolecular Structure & Dynamics (1989) 7:63-69.
"A Sequencing Reality Check," Science (1988) 242:1245.
Craig et al., Nucl. Acids Res. (1990) 18:2653-2660.
Poustka et al., CSH Symp. Quant. Biol. (1986) 51:131-139.
Michiels et al., Cabios (1987) 3:203-210.
Evans et al., Proc. Natl. Acad. Sci. USA (1989) 86:5030-5034.
Chatterjee et al., J. Am. Chem. Soc. (1990) 112:6397-6399.
Frank et al., Bio/Technology (1980) 6:1211-1212.
Knight, Bio/Technology (1989) 7:1075-1076.
Wittman-Liebold (Ed.) Methods in Protein Sequence Analysis Springer-Verlag, New York (1989) Table of Contents, pp. xi-xx.
Atherton et al., Solid Phase Peptide Synthesis: A Practical Approach, IRL Press, London (1989), Table of Contents, pp. vii-ix.
Gait (ed.), Oligonucleotide Synthesis: A Practical Approach, IRL Press, London (1984), Table of Contents, pp. vii-xi.
Duncan et al., Anal. Biochem. (1988) 169:104-108.
Fuller et al., J. Amer. Chem. Soc. (1990) 112:7414-7416.
McCray et al., Ann. Rev. Biophys. and Biophys. Chem. (1989) 18:239-270.
Science, 15 Feb. 1991, vol. 251, pp. 716-717 (Table of Contents), 767-772.
Haridasan et al., "Peptide Synthesis Using Photolytically Cleavable 2-Nitrobenzyloxycarbonyl Protecting Group," Chemical Abstracts, vol. 110, No. 9, Feb. 27, 1989, p. 707, Abstract No. 76031w.
Stueber et al., "Synthesis and Photolytic Cleavage of Bovine Insulin B22-30 on a Nitrobenzoylglycyl-Poly(ethylene Glycol) support," Chemical Abstracts, vol. 100, No. 17, Apr. 23, 1984, p. 700, Abstract No. 139591v.
Levy, "Preparing Additive Printed Circuits," IBM Technical Disclosure Bulletin, vol. 9, No. 11, Apr. 1967, p. 1473.
Gazard et al., "Lithographic Technique Using Radiation-Induced Grafting of Acrylic Acid into Poly(methyl Methacrylate) Films," Chemical Abstracts, vol. 93, No. 11, Dec. 1, 1980, p. 585, Abstract No. 21325r.
Morita et al., "Direct Pattern Fabrication on Silicone Resin by Vapor Phase Electron Beam Polymerization," J. Vac. Sci. Technol., vol. B1, No. 4, Oct.-Dec. 1983, pp. 1171-1173.
Karube, Biosensors: Fundamentals and Applications, Turner et al., eds., Oxford Pub., 1987, pp. 471-480.
Lowe, Trends in Biotechnology (1984) 2:59-65.
Lowe, Biosensors (1985) 1:3-16.
Lowe, Biotechnology and Crop Improvement and Protection, P. Day, ed., BCPC Publications, 1986, pp. 131-138.
Lowe et al., Methods in Enzymology, vol. 137, K. Mosbach, ed., Academic Press, Inc., 1988, pp. 338-348.
Lowe, Phil. Tran. R. Soc. Lond. (1989) 324:487-496.
Ho et al., Anal. Chem. (1987) 59:536-537.
Geysen et al., Proc. Natl. Acad. Sci. USA (1984) 81:3998-4002.
Geysen et al., J. Immunol. Meth. (1987) 102:259-274.
Rodda et al., Mol. Immunol. (1986) 23:603-610.
Geysen et al., Peptides: Chemistry and Biology, G. Marshall, ed., Proceedings of the Tenth American Peptide Symposium, May 23-28, 1987, St. Louis, Mo., pp. 519-523.
Geysen, Immunol. Today (1985) 6:364-369.
Geysen et al., Synthetic Peptides: Approaches to Biological Probes, Alan R. Liss, Inc., 1989, pp. 19-20.
Geysen et al., Science (1987) 235:1184-1190.
Geysen et al., 1986 CIBA Symposium, pp. 130-149.
Geysen et al., Molecular Recognition, vol. 1, No. 1, 1988.
Geysen et al., Mol. Immunol. (1986) 23:709-715.
Patchornik et al., J. Am. Chem. Soc. (1970) 92:6333-6335.
Amit et al., J. Org. Chem. (1974) 39:192-196.
Turner et al., J. Am. Chem. Soc. (1987) 109:1274-1275.
Kaiser et al., Science (1989) 243:187-192.
Corbett et al., J. Org. Chem. (1980) 45:2834-2839.
McGillis, VLSI Technology, S. Sze, ed., McGraw-Hill Book Company, 1983, pp. 267-301.
Yosomiya et al., Polymer Bulletin (1984) 12:41-48.
Lee et al., Macromolecules (1988) 21:3353-3356.
Balachander et al., Tetrahedron Letters (1988) 29:5593-5594.
Pidgeon et al., Analytical Biochemistry (1989) 176:36-47.
Lieberman et al., Science (1990) 247:59-61.
Biotechnology News, vol. 10, No. 3, Feb. 1, 1990, pp. 7-8, "Affymax Raises $25 Million to Develop High Speed Drug Discovery System".
Baum, Chem. & Eng. News (Mar. 5, 1990) pp. 10-11.
Getzoff et al., Science (1987) 235:1191-1196.
Smith et al., Immunochemistry (1977) 14:565-568.
Merrifield, J. Am. Chem. Soc. (1963) 85:2149-2154.
Flanders et al., App. Phys. Lett. (1977) 31:426-428.
Fodor et al., "Light-Directed Spatially-Addressable Parallel Chemical Synthesis," submitted to Science on Oct. 21, 1990.
Applied Biosystems, Model 431A Peptide Synthesizer User's Manual, Sections 2 and 6, Aug. 15, 1989.
Fodor Stephen P. A.
Pirrung Michael C.
Read J. Leighton
Stryer Lubert
Affymax Technologies N.V.
Kaster Kevin R.
Kepplinger Esther L.
Norviel Vern
Nussbacher Kenneth J.
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