Medicaments to combat chronic graft-versus-host diseases

Details Medicaments to combat chronic graft-versus-host diseases Medicaments to combat chronic graft-versus-host diseases

1986-09-25

1990-10-23

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514521, A61K 3142, A61K 31275

Patent

active

049652761

ABSTRACT:
A pharmaceutical composition for use in the treatment of chronic Graft-versus-host diseases as well as autoimmune diseases, in particular for the treatment of systemic lupus erythematosus containing as an active ingredient at least one compound of the formulae 1 or 2 ##STR1## the latter being present per se or in the form of a physiologically tolerable salt.
The invention also relates to a dosage unit form of said pharmaceutical composition and a method of treating chronic Graft-versus host diseases as well as autoimmune diseases, in particular systemic lupus erythematosus.

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V. J. Stecher et al., "Disease Modifying Anti-Rheumatic Drugs", Annual Reports in Medicinal Chemistry, Chapter 18, 1983, pp. 171-179.
R. R. Bartlett et al., "Immunopharmacological Profile of a Novel Isoxazol Derivative, HWA 486, with Potential Antirheumatic Activity. I. Disease Modifying Action on Adjuvant Arthritis of the Rat", Intl. Jur. of Immunopharmacology, vol. 7, No. 1, Jan. 1985, pp. 7-18.
R. R. Bartlett, "Immunopharmacological Profile of HWA 486, a Novel Isoxazol Derivative, II, in Vivo Immunodulating Effects Differ From Those of Cyclophosphamide, Prednisolone, or cyclosporin A," Intl. Jur. of Immunopharmacology, vol. 8, No. 2, Apr. 1986, pp. 199-204.
S. Popovic et al., "The Use of the Murine Chronic Graft Vs. Host (CGVH) Disease, a Model For Systemic Lupus Erythematosus (SLE) for Drug Discovery," Agent and Actions, vol. 21, No. 314, 1987, pp. 284-286.
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