Bicyclic beta-lactam carboxylic acids

Details Bicyclic beta-lactam carboxylic acids Bicyclic beta-lactam carboxylic acids

1988-02-08

1990-10-23

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514195, 540310, C07D49900, A61K 31425

Patent

active

049652605

ABSTRACT:
Compounds of the formula ##STR1## in which R.sub.1 is lower alkyl substituted by hydroxy or by protected hydroxy, R.sub.2 represents carboxy or functionally modified carboxy, R.sub.3 is hydrogen, amino, mono- or di-substituted amino, carbamoyl, hydroxy, protected hydroxy, carbamoyloxy, lower alkoxy, halogen, lower alkanoyl, sulphamoyl or heteroarylthio, each of R.sub.4 and R.sub.5, independently of the other, represents hydrogen, lower alkyl, hydroxy, protected hydroxy, lower alkoxy, halogen, amino, protected amino, lower alkanoylamino or carbamoyl, or R.sub.4 and R.sub.5 together represent methylenedioxy, Y represents a group of the formula --O--, --S-- or --NR.sub.6 --, R.sub.6 is hydrogen or lower alkyl, A.sub.1 represents lower alkylene or unsubstituted or substituted phenylene and A.sub.2 represents a direct bond or lower alkylene, and salts of such compounds, have antibacterial activity. The compounds of the formula I are manufactured by processes that are known per se.

REFERENCES:
patent: 4272437 (1981-06-01), Menard et al.
patent: 4558042 (1985-12-01), Foglio et al.
patent: 4692442 (1987-09-01), Gosteli et al.
patent: 4863914 (1989-09-01), Perrone et al.
patent: 4886793 (1989-12-01), Perrone et al.
Bruna et al., 26th ICAAC 1986 Abstract No. 1286.

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