Prostaglandin I.sub.2 ester and fat emulsion containing the same

Details Prostaglandin I.sub.2 ester and fat emulsion containing the same Prostaglandin I.sub.2 ester and fat emulsion containing the same

1984-06-29

1986-09-23

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3174, C07D30793

Patent

active

046136142

ABSTRACT:
There is provided a new ester of prostaglandin of the formula ##STR1## wherein R.sub.1 denotes an alkyl group having 1 to 20 carbon atoms; R.sub.2 denotes a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms; and X denotes a group represented by the formula ##STR2## The new ester dissolves in oil easier than prostaglandin I.sub.2 itself and can easily be emulsified in the form of particles of solution in a vegetable oil. The ester in the fat emulsion is more stable than prostaglandin I.sub.2 and its physiological acts which are the same as prostaglandin I.sub.2 are prolonged.

REFERENCES:
patent: 4207332 (1980-06-01), Hayashi et al.
patent: 4303671 (1981-12-01), Fitzpatrick
patent: 4430340 (1984-02-01), Cho
patent: 4479944 (1984-10-01), Hayashi et al.
Harrow et al., Textbook of Biochemistry 7th. Ed., W. B. Saunders, pp. 37 and 256-259 (1958).

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