Monoclonal antibody and method of manufacturing hybridoma produc

Details Monoclonal antibody and method of manufacturing hybridoma produc Monoclonal antibody and method of manufacturing hybridoma produc

1988-04-26

1990-10-23

Nucker, Christine

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

43524027, 935104, 935110, 530387, C12N 500, C12P 2100

Patent

active

049651986

ABSTRACT:
A monoclonal antibody specific to a sugar chain containing N-glycolylneuraminic acid and has an ability to bind at least to N-glycolyl GM.sub.2 ganglioside, and producing methods of a hybridomas which produce the monoclonal antibodies are disclosed. The antibodies are extremely useful for clarification of carcinogenesis mechanism, cancer diagnosis and therapy. The hybridomas are manufactured by using an animal with autoimmune disease.

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Fugi, Y., et al., Mol. Immunol. 19, 87-94 (1982).
Male, D. K., et al., Autoimmunity: Experimental Clinical Aspects. Annuals N.Y. Acad. Science vol. 475, 94-105, 1986.
Theofilopoulos, A. N. In: Basic & Clinical Immunology Edited by Stites et al., Lange Medical Publ, of Altos, Calif. pp. 152-186, 1984.
Natoli, et al. Cancer Research 46, 4116-4120, 1986.
Andrezejewski, C., et al. J. Immunol. 126, 226-231.
Livingston, et al. J. Immunol. vol. 135, pp. 1505-1509, 1985.

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