Inverted chimeric oligonucleotides

Details Inverted chimeric oligonucleotides Inverted chimeric oligonucleotides

1997-07-01

1999-10-26

Houtteman, Scott W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 266, C07H 2104

Patent

active

059731362

ABSTRACT:
The invention relates to modified oligonucleotides that are useful for studies of gene expression and for the antisense therapeutic approach. The invention provides inverted hybrid oligonucleotides and inverted chimeric oligonucleotides, both of which produce reduced side effects, relative to traditional phosphorothioate, hybrid or chimeric oligonucleotides.

REFERENCES:
Goodchild, Bioconjugate Chemistry, vol. 2, No. 3, pp. 165-187. May 1990.

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