Vitamin D compound, method of preparing this compound and interm

Organic compounds -- part of the class 532-570 series – Organic compounds – 9,10-seco-cyclopentanohydrophenanthrene ring system or...

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C07C40100

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active

056377428

ABSTRACT:
The invention relates to a new vitamin D compound, substituted in the 18-position with an alkyl group, a hydroxy group, an alkoxy group, an alkenyl group, an alkynyl group, a fluorinated alkyl group or a fluorinated alkenyl group.
The invention also relates to a method of preparing said vitamin D compound and to a lactone and a hydrindane intermediate.
The vitamin D compound is of the general formula ##STR1##

REFERENCES:
patent: 4508651 (1985-04-01), Baggiolini et al.
patent: 4612308 (1986-09-01), Baggiolini et al.
patent: 4755329 (1988-07-01), DeLuca et al.
patent: 4758382 (1988-07-01), Sterling et al.
patent: 4804502 (1989-02-01), Baggiolini et al.
patent: 4866048 (1989-09-01), Calverley et al.
patent: 5237110 (1993-08-01), DeLuca et al.
patent: 5246925 (1993-09-01), DeLuca et al.
patent: 5449668 (1995-09-01), Sestelo et al.
J. Chm. Research Synop., 1990, pp. 240-241, R.L. Dorta et al, "Intramolecular Hydrogen Abstraction. (Diacetoxyiodo) Benzene, . . . ".
Journal of the Chemical Society, Perkin Transactions 1, No. 3 Mar. 1989, pp. 405-411, P. de Armas et al, "Intramolecular . . . ".
Chemische Berichte, vol. 91, No. 4, 1958, Weinheim De, pp. 781-791, H. Inhoffen et al., "Abbau der Vitamine D2 und D3 zum 8-Methyl-trans-hydrindanol-(4)-on-(1)".
Journal of Chemical Research (S), No. 8, 1990, London, GB, pp. 240-241, R. Dorta et al., "Intramolecular Hydrogen Abstraction. (Diacetoxyiodo)-Benzene, a Useful Reagent for the Remote Functionalisation of Non-Activated Carbon Atoms".
Mayo Clinic Proceedings, vol. 56, No. 5, May 1981, Rochester, MN, US, pp. 327-333, R. Kumar et al., "Series on Pharmacology in Practice 11. Vitamin D in the therapy of Disorders of Calcium and Phosphorus Metabolism".
Kidney International Supplement, vol. 38, No. 29, 1990, New York, US, pp. 22-27, A. Brown et al., "New Active Analogues of Vitamin D with Low Calcemic Activity".
Proceedings of the Workshop on Vitamin D, No. 7, 1988, Berlin, DE, pp. 925-934, M. Holick, "Vitamin D and the Skin: Site of Synthesis, Target Tissue and New Therapeutic Approach for Psoriasis".
Proceedings of the Workshop on Vitamin D, No. 7, 1988, Berlin, DE, pp. 1017-1020, E. Ritz et al., "Vitamin D Therapy in Renal Failure--Challenges and Problems for the Future".
Tetrahedron Letters, vol. 33, No. 11, 10 Mar. 1992, Oxford, GB, pp. 1503-1506, M. J. Valles et al., "Functionalization of Vitamin D Metabolites at C-18 and Application to the Synthesis of 1-alpha, 18,25-Trihydroxyvitamin D3 and 18,25-Dihydroxyvitamin D3".
Calverley et al "Vitamin D" in Antitumor Steroids by R.T. Blickenstaff (1992) pp. 193-270.
In re Katz, 215 VSPQ 14(198).

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