Polyvalent hyperimmunoglobulin preparation

Details Polyvalent hyperimmunoglobulin preparation Polyvalent hyperimmunoglobulin preparation

1989-06-23

1990-10-23

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424 858, 424 86, 530387, A61K 3940

Patent

active

049650688

ABSTRACT:
The present invention involves a polyvalent hyperimmunoglobulin preparation having activity against gram negative and gram positive bacteria. Such a polyvalent hyperimmunoglobulin preparation is prepared from plasma, serum or whole blood from donors. Donor selection is based upon titer against E. coli J5 antigen or against lipid A antigen.

REFERENCES:
patent: 4029762 (1977-06-01), Galanos et al.
patent: 4174388 (1979-11-01), McAleer et al.
patent: 4428931 (1984-01-01), Tolman et al.
patent: 4587121 (1986-05-01), Collins et al.
Teng et al., Proc. Natl. Acad. Sci., USA 82, 1790-1794, (1985).
New England Journal of Medicine, 307 (1982), pp. 1225-1230, Braude et al.

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