Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4

Details Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4 Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4

1994-12-13

1997-06-10

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 282, 536 2852, 536 2853, C07H 100

Patent

active

056376880

ABSTRACT:
This invention provides a process for preparing gemcitabine hydrochloride which comprises deblocking .beta.-1-(2'-deoxy-2',2'-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-am inopyrimidin-2-one with a catalytic amount of an alkylamine in the presence of methanol or ethanol in an environment essentially free of water; treating the resulting solution with hydrochloric acid and an antisolvent; and recovering the resulting solid gemcitabine hydrochloride.

REFERENCES:
patent: 3817978 (1974-06-01), Jenkins et al.
patent: 4472386 (1984-09-01), Kodama et al.
patent: 4526988 (1985-07-01), Hertel
patent: 4808614 (1989-02-01), Hertel
patent: 4965374 (1990-10-01), Chou et al.
patent: 5223608 (1993-06-01), Chou et al.

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