Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-11-20
1999-10-26
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514316, 514318, 514320, 514331, A61K 31445
Patent
active
059729627
ABSTRACT:
The use of certain known 1,3,4 trisubstituted 4-aryl-piperidines for the treatment of pruritus in humans and animals is disclosed.
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patent: 5250542 (1993-10-01), Cantrell et al.
D.M. Zimmerman et al., in "Structure --Activity Relationships of trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Antagonists for .mu. and .kappa.-Opioid Receptors," Journal of Medicinal Chemistry, vol. 36, p. 2833 (1993).
Charles H. Mitch et al., in 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: Opioid Antagonists with Potent Anorectant Activity, Journal of Medicinal Chemistry, vol. 36, p. 2842 (1993).
Belfield Eric George
Tommasini Ivan
Ginsburg Paul H.
Henley III Raymond
Pfizer Inc.
Richardson Peter C.
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