Oxime derivatives, their preparation and their therapeutic use

Details Oxime derivatives, their preparation and their therapeutic use Oxime derivatives, their preparation and their therapeutic use

1998-04-21

1999-10-26

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546145, 546165, 514314, A61K 3147, C07D21700

Patent

active

059729597

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen or alkyl; R.sup.2 is alkylene; R.sup.3 is hydrogen, alkyl, alkoxy, alkylthio, halogen, nitro group, amino group, monoalkylamino, dialkylamino, aryl, or aralkyl; X is aryl, or aromatic heterocyclic; Y is oxygen, sulfur or a group of formula >N--R.sup.4, in which R.sup.4 is hydrogen, alkyl or acyl; and Z is a group of formula (Za), (Zb), (Zc) or (Zd): ##STR2## and salts thereof can be used to treat or prevent are included those arising from hyperlipidemia, hyperglycemia, obesity, impaired glucose tolerance (IGT), insulin resistant non-IGT (NGT), non-diagnostic glucose tolerance, insulin resistance, diabetic complications, fatty liver, polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM); in addition the compounds of the present invention have aldose reductase inhibitory activity.

REFERENCES:
patent: 4728739 (1988-03-01), Kees et al.
patent: 5002953 (1991-03-01), Hindley
patent: 5391565 (1995-02-01), Hindley
patent: 5478851 (1995-12-01), Cantello et al.
Takashi Shohda et al, "Studies on Antidiabetic Agents II. .sup.1) Synthesis of 5-[4-(1-Methylcyclohexylmethoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878) and Its Derivatives," Chem. Pharm. Bull. 30, 1982, pp. 3580-3600.

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