Benzimidazolesulfonamide derivatives and pharmaceutical composit

Details Benzimidazolesulfonamide derivatives and pharmaceutical composit Benzimidazolesulfonamide derivatives and pharmaceutical composit

1995-08-04

1997-06-10

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142345, 514253, 544 62, 544370, 544139, A61K 3154, C07D41702

Patent

active

056375867

ABSTRACT:
A benzimidazolesulfonamide derivative of the formula (I): ##STR1## wherein R.sup.1 is an alkyl group of 1 to 6 carbon atoms or a haloalkyl group of 1 to 6 carbon atoms; R.sup.2 is a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a haloalkyl group of 1 to 6 carbon atoms, --OR.sup.4, --O(CH.sub.2).sub.m C.sub.6 H.sub.5, --(CH.sub.2).sub.n C.sub.6 H.sub.5, --NH.sub.2, --NHR.sup.5, --NHC (.dbd.O)R.sup.6, --N(R.sup.7).sub.2, --NHC(.dbd.O) (CH.sub.2).sub.p C.sub.6 H.sub.5, or --NHC(.dbd.O)CH(C.sub.6 H.sub.5).sub.2 ; R.sup.3 is an azole group, --COOH, --COOR.sup.8, or --SO.sub.3 H; A is --O--, --NH--, or --S(O).sub.q --; R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are independently an alkyl group of to 6 carbon atoms; m, n, and p are independently 0 or an integer of 1 to 6; and q is 0, 1, or 2, or a salt thereof; and a pharmaceutical composition comprising the above compound are disclosed. The compound exhibits a stable and strong antagonism to angiotensin II.

REFERENCES:
patent: 4880804 (1989-11-01), Carini et al.
patent: 5137909 (1992-08-01), Chiu et al.
patent: 5336681 (1994-08-01), Imaki et al.
patent: 5399578 (1995-03-01), Buhlmayer et al.
Chemical Abstracts, The American Chemical Society, vol. 58, No. 4, Feb. 18, 1963, pp. 1963.
Carini et al., Nonpeptide Angiotensin II Receptor Antagonists, J. Med. Chem., 34, 2525-2547 1991.

Affiliated with

Also associated with

Rating

Benzimidazolesulfonamide derivatives and pharmaceutical composit does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzimidazolesulfonamide derivatives and pharmaceutical composit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzimidazolesulfonamide derivatives and pharmaceutical composit will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-764807