Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-08-20
1999-10-26
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142345, 514259, 540600, 544259, 544287, 544119, 544289, A61K 31495, C07D23990
Patent
active
059729295
ABSTRACT:
A quinazolinone derivative or a salt thereof expressed by the following Formula (I); ##STR1## wherein each of A and B is R.sup.1 or --(CH.sub.2).sub.n -NR.sup.2 R.sup.3 ; wherein R.sup.1 represents a hydrocarbon group of C.sub.10-30 ; wherein R.sup.2 and R.sup.3 individually represent a hydrogen atom, a lower alkyl group, a phenyl group, or a benzyl group, or together represent a heterocyclic ring having 3-7 members; and n represents an integer of 1-5; wherein when A is R.sup.1, B is --(CH.sub.2).sub.n -NR.sup.2 R.sup.3 and when A is --(CH.sub.2).sub.n -NR.sup.2 R.sup.3, B is R.sup.1 ; and wherein R.sup.4 is selected from the group consisting of a hydrogen atom, a halogen atom, a lower alkyl group, a lower acyl group, a nitro group, a cyano group, an amino group, a lower alkoxycarbonyl group, a lower alkylamino group, a lower alkoxy group, a lower acyloxy group, a carbamoyl group, a lower alkylcarbamoyl group, and a lower acylamino group. The quinazolinone derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in humans.
REFERENCES:
patent: 2408633 (1946-10-01), Guenther et al.
patent: 3558610 (1971-01-01), Breuer et al.
patent: 4710502 (1987-12-01), Wright
patent: 4753944 (1988-06-01), Wright
patent: 5093364 (1992-03-01), Richards et al.
patent: 5756502 (1998-05-01), Padia
patent: 5763608 (1998-06-01), Bhattacharya et al.
Hamad, et al. "Some Reactions of 2-(.alpha.-Naphthyl Methyl)-(4H)-3,1 Benzoxazin-4-One", Pakistan Journal of Scientific and Industrial Research, vol. 36, No. 6-7, pp. 228-231. Jun.-Jul. 1993.
Database WPI, Week 9550, Derwent Publications, Ltd. London, GB, AN 95-385642, XP002089827 JP 07 258224 A (Daiichi Pharm. Co., Ltd.) Oct. 9, 1995.
Soc. Chimique Buzas, A., et al. Derives Pharmacologiquement actifs des quinazolonge-4 substitues en -3 Memoires Presentes A La Societe Chimique, 5e Serie pp. 1889-1891 (esp. Compound No. 10-13 and 15-16) 1959.
J Ind Chem Soc Singh, P Study in Nitrogen Mustards. Part II: Synthesis of Some 2-Alkyl-3-aryl-4(3H)-quinazolinone Derivatives as Possible Antitumour Agents, vol.LV, Aug. 1978 (pp. 801-805).
Bull Soc Chim Fr N.degree..333--Composes Sulfures Heterocycliques. 81--Aminoakyl-3 3 H-quinzaolinones-4, 1976 N.degree.. 11-12 (pp. 1853-1856 --esp. Table III).
Ind. J. of Chem Seth, M Syntheses of 2-Substituted & 2,3 Disubstituted 4(3H)-Quinazolones, vol. 14B, Jul. 1976 (pp. 536-540).
Ind J of Pharm Joshi, LD Inhibition of Rat Brain Acetylcholinesterase by Substituted Quinazolones, vol. 33, No. 5 (pp. 80-82) 1961.
J Prakt Chem Klosa, V Synthese von 2,3-substituierten Chinazolon-(4)-derivaten mit Hilfe von Phosphoroxychlorid, 4 Riche, Band 14, 1961 (pp. 84-98--esp. Compound No.49-53).
Fukunishi Hirotada
Kobayashi Koji
Magara Tsunao
Chao Fei-Fei
Raymond Richard L.
Razgunas Ann
Shiseido Co. Ltd.
Snider Ronald R.
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