Stable protein solutions for diagnostics and method of making an

Details Stable protein solutions for diagnostics and method of making an Stable protein solutions for diagnostics and method of making an

1995-05-19

1998-10-06

Feisee, Lila

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is particulate and the particles are of...

436518, 436524, 436525, 436526, 436527, 436528, 436529, 436530, 436531, 435 4, 435 71, 435 72, G01N 33543, G01N 33551, G01N 33553, G01N 33552

Patent

active

058175253

ABSTRACT:
The present invention features stable bulking agents and blocking agents for solid phase materials containing proteins. The proteins have thiol groups which are blocked or chemically inert, preventing the formation of aggregates. Chemical solutions wherein thiol groups, if present, are blocked or chemically inert, are particularly useful in analytical applications and in diagnostic reagents utilizing solid phase materials or particles.

REFERENCES:
patent: 4554088 (1985-11-01), Whitehead
Sigma Catalogue; Biochemicals, Organic Compounds for Research and Diagnostic Reagents; 1991 XPOO2013871; Product nrs. A 6285 and A 0161.
Liu, Robert W. et al., Moisture-Induced Aggregation of Lyophilized Proteins in the Solid State, Biotechnology & Bioengineering, 37, pp. 77-184 (1991).

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