Controlled absorption naproxen formulation for once-daily admini

Details Controlled absorption naproxen formulation for once-daily admini Controlled absorption naproxen formulation for once-daily admini

1994-04-14

1997-06-10

Bawa, Raj

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424451, 424459, 424458, 424457, 424464, 424469, 424468, 424471, 424490, A61K 954

Patent

active

056373201

ABSTRACT:
A once-daily naproxen formulation for oral administration having a first portion of the naproxen as a multi-particulate pellet form, each pellet having a core of naproxen or a pharmaceutically acceptable salt thereof in association with an organic acid, the core being surrounded by a multi-layer membrane and optionally a second portion of naproxen formulated to release the drug promptly following oral administration.

REFERENCES:
patent: 4783337 (1988-11-01), Wong et al.
patent: 4803079 (1989-02-01), Hsiao et al.
patent: 4867984 (1989-09-01), Patel
patent: 5024842 (1991-06-01), Edgren
J.G. Kelly, C.D. Kinney, J.G. Devane, S. Mulligan & B.V. Colgan--"Pharmacokinetic properties and clinical efficacy of once-daily sustained-release naproxen", Eur. J. Clin. Pharmacol (1989) 36:383-388.

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