Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-08-27
1999-10-26
Fredman, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 5, 435 911, 536 221, 536 231, 536 243, 536 2431, 536 2433, 530300, 530350, 436501, 436518, C12Q 168, C07H 2104, C07K 1300, G01N 3353
Patent
active
059726083
ABSTRACT:
Disclosed are new nucleosome arrays that can be used in assays that couple the activity of a chromatin remodeling enzyme (or enzyme complex) to the activity of a restriction endonuclease to quantitatively measure the extent of "remodeling" activity exhibited by a particular remodeling enzyme or enzyme complex. Further, the new nucleosome arrays can be used in methods for screening candidate modulators, i.e., inhibitors or enhancers, of chromatin remodeling enzymes or enzyme complexes.
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Logie Colin
Peterson Craig L.
Fredman Jeffrey
University of Massachusetts
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