Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Patent
1998-03-30
1999-10-26
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
435238, A01N 102, C12N 706
Patent
active
059725931
ABSTRACT:
Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
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Isaacs Stephen T.
Rapoport Henry
Spielmann Hans Peter
Wollowitz Susan
Carroll Peter G.
Cerus Corporation
Saucier Sandra E.
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