Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1996-08-23
1999-10-26
Eisenschenk, Chris
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4241341, 4241471, 4241491, 4241841, 4241991, 4242041, A61K 3929, A61K 3900, A61K 3912, A61K 3942
Patent
active
059723475
ABSTRACT:
The invention relates to a pharmaceutical composition for prophylactic and/or therapeutic treatment of patients for immunization against a virus infection and is characterized in that this is obtainable by neutralizing the enriched and/or purified virus with antibodies. The invention further comprises a kit for the production of this composition as well as the use of a virus neutralized with antibodies for the production of a pharmaceutical composition.
REFERENCES:
patent: 4493825 (1985-01-01), Platt et al.
Shimizu et al., J. Virol. 68(3):1194-1500, 1994.
Andre et al. "Inactivated Candidate Vaccines for Hepatitis A" In: Progress in Medical Virol., Melnick, Ed., Basel, Karger, 1990, vol. 37,pp. 72-95.
Hedenstrom et al., Vaccine, 13(8): 759-762, 1995.
Jilg, Wolgang et al. "Hepatitis A Vaccine" In: Vaccines, 2.sup.nd Edit., Plotkin & Mortimer, Eds. W.B. Saunders Comp., Philadelphia, pp. 583-595, 1994.
Miriam Alter, Archives of Pathology and Laboratory Medicine 118(4):342-345, 1994.
Zuckerman et al., J. Hepatology, 22(Suppl. 1): 97-100, 1995.
Haynes, Science, 260: 1279-1286, 1993.
Emini, E.A. Aids Vaccine Research & Clinical Trials. Putney SD & Bulognesi DP, Eds. New York, Marcel Dekker pp. 369-378, 1990.
Spichtin et al., "Ultrastructural Alterations In Hepastocytes And Sinus Endothelia In Expeimental Non-A, Non-B Hepatitis In Chimpanzee With And Without Immunoglobulin Prophylaxis", journal of Medical Virology, vol. 12:215-226, (1983).
Eder et al., "Transmission of Non-A, Non-B Hepatitis to Chimpanzees: A Second and Third Episode Caused by the Same Inoculum", Viral Hepatitis and Liver Disease, pp. 550-552, (1988).
Leibl et al., "Multiple Infusions of Human Intravenous Immunoglobulin in Chimpanzees Do Not Lead to Immune Elimination", Clin. exp. Immunol., vol. 81:454-458, (1990).
Prince et al., "Immunity in Hepatitis C Infection", The Journal of Infectious Diseases, Vlo. 165:438-443, (1992).
Farci et al., "Lack of Protective Immunity Against Reinfection with Hepatitis C Virus", Science, vol. 258:135-140, (1992).
Gollins et al., "A New Mechanism for the Neutralization of Enveloped Viruses by Antiviral Antibody", Nature, vol. 321:244-246, (1986).
Hedenstroem et al., "Vaccination Against Tick-borne Encephalits (TBE): Influence of Simultaneous Application of TBE Immunoglobulin on Seroconversion and Rate of Adverse Events", Vaccine, vol. 13(6):750-762, (1995).
Tabor et al., "Primate Animal Models and Titered Inocula for the Study of Human Hepatitis" J. Med. Primatol., vol. 12:305-318, (1983).
Guidelines of the German Pharmacopia DAB 10 (3rd supplement 1994) "Immunglobulin vom Menschen Zur Intravenoesen Anwendung".
Eder et al., "Safety Testing of Blood Products in Chimpanzees", Symp. Vienna,pp. 156-165, (1994).
Thefeld et al., "Reference Values for the Determination of GOT, GPT, and Alkaline Phosphatase in Serum With Optimal Standard Methods", Dtsch. Med. Wschr., vol. 994:343-351, (1974).
Lehrbuch et al., "Synopsis Der Leberkrankheiten", Thieme Verlag Stuttgart, Table of Contents, (1974).
Schmidt et al., "Clinical Pathology of Viral Hepatitis", Laboratory and Clinical Science, pp. 411-487, (1983).
Klin. Gastroenterologie in 2 Baenden, Thieme Verlag, Stuttgart (1984), Laboruntersuchungen, Chapter by Wuest.
Rosalki et al., "Serum .gamma.-Glutamyl Transpeptidase Activity in Alcoholism", Clin. Chem. Acta, vol. 39:41-47, (1972).
Rosalki, "Gamma-Glutamyl Transpeptidase", Chem. Chem., vol. 7:53-107, (1975).
Valcnza et al., "The Clinical Chemistry of Chimpanzees", J. Med. Primatol., vol. 14:350-315, (1985).
Weill et al., "The Predictive Value of Gamma-Glutamyl Transferase and Other Peripheral Markers in the Schreening of Alcohol Abuse", Advances in Biomedical Pharmacology, 3rd Series, Masson, Paris, pp. 195-198, (1982).
Persijn et al., "A New Method for the Determination of .gamma.-Glutamyltransferase in Serum", J. Clin. Chem. Clin. Biochem., vol. 14(9):421-427, (1976).
Ishak et al., "Histological Grading and Staging of Chronic Hepatitis", Journal of Hepatology, vol. 22:696-699, (1995).
Pfeifer et al., "Experimental Non-A, Non-B Hepatitis: Four Types of Cytoplasmic Alteration in Hepatocytes of Infected Chipanzees", Virchows Arch. B Cell Path., vol. 33:233-243, (1980).
Schaff et al., "Ultrastructural Alterations in Serial Liver Biopsy SpeicmensFrom Chimpanzees Experimentally Infected with a Human Non-A, Non-B Hepatitis Agent", Virchows Arch [Cell Pathol], vol. 45:301-312, (1984).
Schaff, "Intracytoplasmic Crystalline Inclusions in the Hepatocytes of Humans and Chimpanzees", Ultrastructural Pathology, vol. 14:303-309, (1990).
Shimizu et al. J. Virol. 68(3): 1494-1500, Mar. 1994.
Jilg et al. "Hepatitis A Vaccines", In: Vaccines 2nd Edition, Plotkin et al. eds., W.B Saunders Company, Philadelphia, pp. 583-595, 1994.
Randall et al. Vaccine 12(4): 351-358, 1994.
Celis et al. Science 224:297-299, 1984.
Hedenstrom et al. Vaccine 13(8): 759-762, 1995.
Marusic-Galesic et al. Immunology 72: 526-531, 1991.
Miriam Alter Archives of Pathology and Laboratory Medicine 118(4):342-345, 1994.
Zuckerman et al. J. Hepatology 22(Suppl. 1:97-100, 1995.
Haynes et al. Science vol. 260: 1279-1286, 1993.
Cruse & Lewis, Illustrated Dictionary of Immunology, CRC Press, Inc., New York, p. 73, 1993.
Arvies et al. Immunology 65: 229-235, 1988.
Eder Gerald
Eibl Johann
Baxter Aktiengesellschaft
Eisenschenk Chris
Zeman Mary K
LandOfFree
Pharmaceutical composition containing a neutralized virus and us does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical composition containing a neutralized virus and us, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical composition containing a neutralized virus and us will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-760732