Products extracted from a plant of the genus Commiphora, particu

Details Products extracted from a plant of the genus Commiphora, particu Products extracted from a plant of the genus Commiphora, particu

1998-05-20

1999-10-26

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

424401, 514844, 514845, 514846, 514847, 514944, 560174, 568374, A61K 3578, A61K 748

Patent

active

059723416

DESCRIPTION:

BRIEF SUMMARY
BACKGROUND OF THE INVENTION

The invention relates to the use in cosmetics of extracts of a plant of the genus Commiphora, particularly the plant Commiphora mukul, especially as an agent with antiwrinkle activity. It further relates, by way of novel industrial products, to two particularly active products isolated from these extracts, and to derivatives of these novel products.
It is known that the plant Commiphora mukul belongs to the family of the Burseraceae. Commiphora mukul is a plant of Indian origin which is very widely used in traditional Indian medicine and in ayurvedic medicine. A resin produced by Commiphora mukul, which is also called guggul, is used in particular in these applications. This ayurvedic treatment was known to comprise the treatment of obesity and lipidic disorders, as well as rheumatic diseases.
It should be noted that the term "guggul" denotes both the plant and the resin it produces. Also, this plant is a small tree or a shrub of 1.2 to 1.8 m in height, which grows essentially in India, and the gum resin can be harvested in the ordinary way by making an incision in the plant.
U.S. Pat. Nos. 4,847,071, 4,847,069, 4,946,671 and 4,954,332 have recently described topical compositions, containing free radical absorbers and an anti-inflammatory agent, for protecting against UV radiation. Guggal or guggul extract is among the numerous anti-inflammatory agents mentioned.
Furthermore, document EP-A-513 671 has also disclosed compositions containing, as the active ingredient, a total lipophilic extract of the plant Commiphora mukul, which is obtained in particular from the resin of the bark of Commiphora mukul. This extract contains a high proportion of guggulsterones. This composition is described as having an anti-inflammatory, immunomodulating or antiandrogenic activity for the treatment of acne and benign hypertrophy of the prostate.


SUMMARY OF THE INVENTION

It has now been discovered, surprisingly and unexpectedly, that extracts of a plant of the genus Commiphora, particularly the plant Commiphora mukul, have an antiwrinkle activity and can thus be used as cosmetic agents for improving the surface appearance of the skin and particularly for reducing the depth of large wrinkles and eliminating small wrinkles.
On the basis of this discovery, the Applicant carried out complementary systematic studies aimed at identifying particularly active fractions responsible for this activity. It found in particular that these fractions contained two novel products which were particularly active as regards the activity in question. These products could be isolated and totally identified from extracts of the plant Commiphora mukul. They therefore constitute novel industrial products which have a remarkable activity as cosmetic agents for combating wrinkles.


DETAILED DESCRIPTION OF THE INVENTION

The invention further relates to derivatives of the two novel products isolated according to the invention.
Thus, according to a first aspect, the invention relates to the products of formula (I): ##STR1## in which R is: a) a CH.sub.2 OH group or
The invention relates very particularly, by way of novel industrial products, to the products of formula (II): ##STR2## in which R is: a) a CH.sub.2 OH group, the product being denoted by formula II.sub.a, ##STR3## in which R.sub.1 is a linear or branched alkyl group containing from 1 to 6 carbon atoms, particularly the methyl group, potassium, or a quaternary ammonium or amine group, preferably calcium, or group containing from 1 to 6 carbon atoms.
The invention relates very particularly to the two novel industrial products denoted respectively by II.sub.a and II.sub.b and having the following formulae: ##STR4##
The two products could be isolated from the plant Commiphora mukul and were completely identified by different analytical techniques, as will become apparent from the following description.
The product of formula II.sub.a, the empirical formula of which is C.sub.30 H.sub.50 O.sub.3, will be referred to as "commipherol". Its nomenclature is as follows:

REFERENCES:
patent: 4847069 (1989-07-01), Bissett et al.
patent: 4847071 (1989-07-01), Bissett et al.

Affiliated with

Also associated with

Rating

Products extracted from a plant of the genus Commiphora, particu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Products extracted from a plant of the genus Commiphora, particu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Products extracted from a plant of the genus Commiphora, particu will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-760707